Ipratropium Bromide

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Ipratropium Bromide

  Action
  Indications
  Contraindications
  Route/Dosage
  Interactions
  Lab Test Interferences
  Adverse Reactions
  Precautions
Patient Care Considerations
  Administration/Storage
  Assessment/Interventions
  Patient/Family Education


(IH-pruh-TROE-pee-uhm BROE-mide)
Atrovent, Apo-Ipravent, Novo-Ipramide, PMS-Ipratropium
Class: Respiratory inhalant/Anticholinergic

 Action Antagonizes action of acetylcholine on bronchial smooth muscle in lungs, causing bronchodilation.

 Indications

Bronchospasm: Maintenance treatment of bronchospasm associated with COPD, including chronic bronchitis and emphysema, used alone or in combination with other bronchodilators (especially beta-adrenergics). Rhinorrhea: Symptomatic relief of rhinorrhea associated with allergic and nonallergic rhinitis and symptomatic relief of rhinorrhea associated with the common cold in patients ³ 12 yr for aerosol and solution, ³ 6 yr for 0.03% nasal spray, and ³ 5 yr for 0.06% nasal spray.

 Contraindications Hypersensitivity to atropine or any anticholinergic derivatives or to soya lecithin or related food products.

 Route/Dosage

ADULTS: Aerosol/Inhalation: 2 inhalations (36 mcg) qid (max 12 inhalations/24 hr). Do not exceed 12 inhalations in 24 hours. Solution: 500 mcg (1 unit dose vial) administered 3 to 4 times a day by oral nebulization, with doses 6 to 8 hr apart. The solution can be mixed in the nebulizer with albuterol if used within 1 hr.

Spray 0.03 formulation: 2 sprays (42 mcg) per nostril 2 or 3 times daily (optimum dose varies). 0.06 formulation: 2 sprays (84 mcg) per nostril 3 or 4 times daily (optimum dose varies).

 Interactions

Anticholinergics: There is some potential for additive anticholinergic effects when administered with other anticholinergic agents.

 Lab Test Interferences None well documented.

 Adverse Reactions

CV: Palpitations; hypertension; aggravated hypertension. RESP: Cough; exacerbation of symptoms. CNS: Nervousness; dizziness; headache. EENT: Blurred vision; local irritation. For the 0.06 nasal spray formulation only: Epistaxis; nasal dryness; nasal congestion; taste perversion; nasal burning; conjunctivitis; hoarseness; pharyngitis. GI: Nausea; dry mouth; GI distress; constipation. DERM: Rash. OTHER: Arthritis.

 Precautions

Pregnancy: Category B. Lactation: Undetermined. Children: Safety and efficacy in children < 12 yr not established for aerosol and solution; < 6 yr for 0.03% nasal spray; < 5 yr for 0.06% nasal spray. Special risk patients: Use drug with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, bladder neck obstruction due to increased risk for precipitation or worsening of underlying disease. Acute bronchospasm: Not indicated for initial treatment of acute episodes of bronchospasm in which rapid response is required. For relief of bronchospasms in acute exacerbations of COPD, drugs with faster onset may be preferable as initial therapy. The combination of ipratropium and beta agonists in the relief of bronchospasms associated wtih COPD has not been demonstrated to be more efficacious than either drug alone.


PATIENT CARE CONSIDERATIONS


 Administration/Storage

Inhalation

Nasal spray

Solution

 Assessment/Interventions

 Patient/Family Education

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© 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts